Mechanical Properties of Oi Type Iii Human Bone Tissue Measured by Nanoindentation
نویسندگان
چکیده
+Fan, ZF; *Smith, PA, +Harris,GF; [email protected] +Orthopaedic & Rehabilitation Engineering Center (OREC) Marquette University/Medical College of Wisconsin, Milwaukee, WI *Shriners Hospital for Children, Chicago, IL Introduction: Nanoindentation was used to characterize the intrinsic mechanical properties of bone tissue from eight (8) children with type III Osteogenesis Imperfecta (OI). Unlike normal bone tissue, OI type III cortical bone exhibited more isotropic material properties. Young’s modulus and hardness values measured in the longitudinal direction did not show significant differences from the transverse measurements. No differences were observed in modulus or hardness in an analysis of the cortical and trabecular samples. The increases in isotropic and homogeneous material properties of the OI bone resulted from distortions in the collagen network. Both cortical and trabecular bone demonstrated decreased mechanical properties (modulus, hardness) when compared to normal (adult) bone. These decreases were greatest in the cortical bone. The deformation patterns of the OI type III bone during nanoindentation were similar to those of normal adult bone.
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Decreased Bone Material Strength in Severe Osteogenesis Imperfecta (oi)
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